This study was designed to determine whether pulsed electromagnetic field therapy (PEMFT) could alleviate common symptoms of arthritis such as pain, swelling and immobility and whether it could contribute to overall wellbeing. Five volunteers, all of whom were diagnosed with osteoarthritis, participated in the study. Subjects treated themselves with the Centurion EZY system for 20 minutes, two to three times per week for four weeks. Subjects were tested for various physiological parameters including blood pressure, heart rate variability, balance of the autonomic nervous system (ANS), and stress at the beginning of the trial and at the end. An electro-interstitial scan was conducted to provide additional wellness parameters and a photograph was taken to document range of motion. Results were assessed on a case-by-case basis. PEMFT improved mobility in two of the cases after just one treatment and reduced pain and/or swelling in four of the five cases within 4 weeks. Additionally, general wellness related to cardiovascular health and balance of the ANS of participants improved throughout the course of the study. PEMF therapy may be a useful form of therapy to promote healing and to reduce symptoms of pain, swelling and immobility among patients with osteoarthritis. Furthermore, these treatments may have overall benefits to the health of the cardiovascular and the autonomic nervous system. Further testing needs to be done with a larger sample size to confirm these initial findings.