Bone healing

High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field

Zedong Yan, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing, 1 ,† Dan Wang, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing, 1 ,† Jing Cai, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, 2 ,† Liangliang Shen, Investigation, Methodology, Validation, 3 Maogang Jiang, Formal analysis, Funding acquisition, Methodology, Validation, 1 Xiyu Liu, Formal analysis, Investigation, Methodology, Resources, Validation, 1 Jinghui Huang, Conceptualization, Investigation, Methodology, Validation, 4 Yong Zhang, Investigation, Methodology, Resources, Validation, 5 Erping Luo, Formal analysis, Funding acquisition, Resources, Validation, 1 and Da Jing, Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing Abstract Radiotherapy increases tumor cure and survival rates; however, …

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Pulsed electromagnetic field (PEMF) transiently stimulates the rate of mineralization in a 3-dimensional ring culture model of osteogenesis

Abstract Pulsed Electromagnetic Field (PEMF) has shown efficacy in bone repair and yet the optimum characteristics of this modality and its molecular mechanism remain unclear. To determine the effects of timing of PEMF treatment, we present a novel three-dimensional culture model of osteogenesis that demonstrates strong de novo generation of collagen and mineral matrix and exhibits stimulation …

Pulsed electromagnetic field (PEMF) transiently stimulates the rate of mineralization in a 3-dimensional ring culture model of osteogenesis Read More »

Microcirculatory effects of pulsed electromagnetic fields

Abstract Purpose: Pulsed electromagnetic fields (PEMF) are used clinically to expedite healing of fracture non-unions, however, the mechanism of action by which PEMF stimulation is effective is unknown. The current study examined the acute effects of PEMF stimulation on arteriolar microvessel diameters in the rat cremaster muscle. The study hypothesis was that PEMF would increase arteriolar …

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Pulsed Electro-Magnetic Field (PEMF) Effect on Bone Healing in Animal Models: A Review of Its Efficacy Related to Different Type of Damage

March 5, 2022 Simple Summary Pulsed electromagnetic fields (PEMFs) are a type of biophysical stimulation that has been shown to be effective in improving bone regeneration and preventing bone loss. Their use dates back to the 1970s, but a gold standard treatment protocol has not yet been defined. PEMF efficacy relies on the generation of …

Pulsed Electro-Magnetic Field (PEMF) Effect on Bone Healing in Animal Models: A Review of Its Efficacy Related to Different Type of Damage Read More »

A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats

Abstract Pulsed electromagnetic field (PEMF) treatments stimulate bone formation activities though further work is needed to optimize its therapeutic benefit. PEMF can generate local potential gradients and electric currents that have been suggested to mimic bone electrochemical responses to load. In line with this reasoning, a recent publication reported that PEMF application on isolated bone …

A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats Read More »

Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery

Abstract The finding that alterations in electrical potential play an important role in the mechanical stimulation of the bone provoked hype that noninvasive extremely low frequency pulsed electromagnetic fields (ELF-PEMF) can be used to support healing of bone and osteochondral defects. This resulted in the development of many ELF-PEMF devices for clinical use. Due to …

Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery Read More »

Effect of pulsed electromagnetic field on mandibular fracture healing: A randomized control trial, (RCT)

Abstract Introduction: Currently, the pulsed electromagnetic field (PEMF) method is utilized for the treatment of nonunion long bone fractures. Considering the established effect of the PEMF on the acceleration of the bone healing process, we conducted this study to evaluate the effect of PEMF on the healing process in mandibular bone fractures. Material and methods: This research …

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Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses

Abstract Pulsing electromagnetic fields (PEMFs) induce weak electric currents in bone by external coils on casts or skin. This surgically noninvasive, outpatient method, approved by the Food and Drug Administration in November 1979, produced confirmed end results in 1,007 ununited fractures and 71 failed arthrodeses, worldwide. Overall success at Columbia-Presbyterian Medical Center was 81%; internationally, …

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Beneficial Effects of Electromagnetic Fields

This review article claims that over a quarter of a million patients worldwide with chronically ununited fractures have experienced beneficial results from treatment with pulsed electromagnetic fields. In addition, the author cites studies pointing to the treatment’s efficacy with respect to other conditions such as nerve regeneration; wound healing, graft behavior, diabetes, heart attack, and …

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Fundamental and Practical Aspects of Therapeutic Uses of Pulsed Electromagnetic Fields (PEMFs)

Noting that beneficial effects of low-energy, time-varying magnetic fields have been shown since the early 1970s, this review article cites studies pointing to its success in the treatment of a wide range of conditions. The best results for this modality obtained in the area of bone healing. C.A. Bassett, “Fundamental and Practical Aspects of Therapeutic …

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