Home / Research / by Art Crotty

Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats

Abstract

Deep brain stimulation of the subthalamic nucleus is an established therapeutic strategy for patients with Parkinson’s disease. Although the exact mechanisms of action remain unknown, it is noteworthy that dopaminergic medication can be markedly reduced after neurostimulation of the subthalamic nucleus. Previously, we have shown that deep brain stimulation of the subthalamic nucleus is followed by an increase of striatal extracellular dopamine metabolites in naive rats. In the present study we examined the effects of deep brain stimulation on striatal monoamine metabolism in the intrastriatal 6-hydroxydopamine rat model of Parkinson’s disease. Deep brain stimulation of the subthalamic nucleus was followed by a delayed increase of extracellular 3,4-dihydroxyphenylacetic and homovanillic whereas dopamine levels were unchanged in stimulated rats and controls. Our results indicate that deep brain stimulation of the subthalamic nucleus affects significantly striatal dopaminergic metabolism in 6-hydroxydopamine lesioned rats.

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11323111&dopt=Abstract
Neurosci Lett 2001 May 11;303(3):165-8
Meissner W, Reum T, Paul G, Harnack D, Sohr R, Morgenstern R, Kupsch A.
Department of Neurology, Charite Campus Virchow-Klinikum, Humboldt-University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Share this story, choose your platform!

Have a Question?

The Association of PEMF Professionals connects practitioners all over the world to ensure those interested in PEMF can access a professional nearby.
Complete the form below and we will be in touch soon.
Contact Us

Become a Member

Research

Gain access to all our research articles

Discounts

Use our Member Discounts Program

Certifications

Get AOPP Certified
You are enjoying 1 of 2 free previews