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Preliminary evidence for a beneficial effect of low-frequency, repetitive transcranial magnetic stimulation in patients with major depression and schizophrenia

Abstract

OBJECTIVE:

This study was designed to evaluate the potential efficacy of repetitive transcranial magnetic stimulation (rTMS) at low-frequency in patients with major depression and schizophrenia.

EXPERIMENTAL DESIGN:

We investigated the therapeutic effect of a course of 10 rTMS sessions in 14 subjects with major depression (MD) and 10 with schizophrenia.

PRINCIPAL OBSERVATIONS:

Seven of the depressed patients reported significant improvement in depressive symptomatology, and seven of the schizophrenic subjects reported amelioration of anxiety and restlessness.

CONCLUSIONS:

These preliminary results suggest that low-frequency rTMS may be beneficial mainly in MD and to some extent in schizophrenia, and support the need for controlled studies to further validate its therapeutic potential.

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9614593&dopt=Abstract
Depress Anxiety 1998;7(2):65-8
Feinsod M, Kreinin B, Chistyakov A, Klein E.
Department of Psychiatry, Rambam Medical Center, Haifa, Israel.

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